| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Amyloid-β Impedance Sensor Based on Caffeine for Alzheimer’s Disease |
| 초록 |
In this work, we prepared an electrochemical sensor for the detection of amyloid beta oligomer (AβO) using caffeine, which is an outstanding inhibitor to suppress the Aβ aggregation through hydrophobic interactions between the hydrophobic chain of caffeine and the nonpolar regions of the AβO. Amino group modified caffeine (caffeine-NH2) was immobilized on 3-mercaotopropionic acid self-assembled gold electrode. The step immobilization and the sensing performance of caffeine toward AβO were confirmed by a cyclic voltammetry (CV) and an electrochemical impedance spectroscopy (EIS), respectively. The differences in electron-transfer resistance showed a proportional increase as concentrations of AβO change form from 10-5 nM to 1 nM. The developed caffeine sensor could provide a promising sensing platform for the detection of AβO and monitoring of Alzheimer’s disease. |
| 저자 |
JIELING QIN1, 조미숙2, 이영관2
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| 소속 |
1Sungkyunkwan Univ., 2성균관대 화학공학부 |
| 키워드 |
amyloid beta; caffeine; electrochemical sensor; Alzheimer's disease
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| E-Mail |
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