| 학회 |
한국화학공학회 |
| 학술대회 |
2021년 봄 (04/21 ~ 04/23, 부산 BEXCO) |
| 권호 |
27권 1호, p.509 |
| 발표분야 |
생물화공 |
| 제목 |
Multi-Stimuli Responsive Functional Hollow Silica Nanoparticles for Hyaluronic acid-guided Delivery |
| 초록 |
Stimuli-responsive nanocarriers have been studied for controlling the release kinetics with minimizing undesired leakage of loaded molecules. Mesoporous silica nanoparticle (MSN) has been used as a promising carrier owing to its good biocompatibility, high surface area, and easy in chemical modification. Moreover, introducing targeting moieties onto the MSN enable to achieve targeted delivery to designated sites. Here, we design a multi-responsive MSN capped with diverse molecular weight of hyaluronic acid (HA) for controlling the loading efficiency and enhancing the targeting efficiency. We synthesize dual-responsive MSNs via several surface modified processes. Modified MSNs are further functionalized with HA to provide the targeting properties owing to affinity to CD44 rich cancer cells. Drug release is tested using doxorubicin in presence of external stimuli such as pH and glutathione levels. The targeting ability of HA is examined with cancer cell comparing with the normal cell. We expect that the proposed HA-capped MSN would be a promising carrier to enhance drug delivery efficiency with targeting/stimuli-responsive functionalities. |
| 저자 |
신동훈1, 이승기1, 장현성2, 주지봉2, 최인희1
|
| 소속 |
1서울시립대, 2건국대 |
| 키워드 |
생물화학공학 |
| E-Mail |
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| 원문파일 |
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