| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
X-ray & Neutron Scattering for Polymer Science |
| 제목 |
The role of electrostatic interactions in structural stability and dynamic flexibility of RNA |
| 초록 |
Charge neutralization of RNAs nucleates self-assembly into folded structures critical for their biological functions. However, thermodynamic interplay between electrostatic and tertiary interactions upon folding and conformational fluctuation remains largely unexplored, although it is directly linked to both non-equilibrium and equilibrium energy landscape of RNA folding. Time-resolved SAXS studies show that multiphasic folding of RNA varies with electrostatic natures and potentials. According to quasielastic neutron scattering studies, sub-ns dynamics of RNA increases with cations, while they stabilizes the folded structure. Similar cation-induced flexibility observed in a sulfonated PS indicates that local motions of RNA follow polyelectrolyte effects rather than specific interactions pertaining to its biological structures. Comparison between structural stability and dynamic flexibility proposes a thermodynamic expression that links electrostatic interactions to molecular mechanics. |
| 저자 |
노준호1, Madhu Tyagi2, Alexei P. Sokolov3, R. M. Briber4, Sarah A. Woodson5
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| 소속 |
1기초과학(연), 2복잡계 자기조립 연구단, 3Center for Neutron Research, 4National Institute of Standards and Technology, 5Department of Chemistry |
| 키워드 |
RNA; folding; dynamics; time-resolved SAXS; quasielastic neutron scattering
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| E-Mail |
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