| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.346 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Sol-gel transition of thermosensitive chitosan-based hydrogel depending on the pH and temperature to use as injectable biomaterials |
| 초록 |
A novel injectable thermosensitive in situ gelling hydrogel has been developed. This study demonstrate that chitosan solutions can be neutralized up to physiological pH (~7.2) using β-glycerol phosphate. The addition of the particular basic salt, β-glycerol phosphate, provides the correct buffering and other physicochemical conditions including control of hydrophobic interactions and hydrogen bonding which are necessary to retain chitosan in solution at neutral pH near 4 ℃. Indeed, the chitosan solution was to allow gel formation upon heating to 37 ℃. The form of chitosan solution observed the endothermic gelation in mice and allowed the establishment of a sol-gel transition from pH and temperature. We suggest that the gelation process appears to be governed by delicate interaction between pH and temperature and to use this thermosensitive hydrogel for the local delivery from the injected subcutaneously implanting. |
| 저자 |
한희동1, 신병철1, 김승수1, 최호석2
|
| 소속 |
1한국화학(연), 2충남대 |
| 키워드 |
chitosan; thermosensitive hydrogel
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| E-Mail |
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