| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Microneedle Biosensor for Real-Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy |
| 초록 |
We fabricated a microneedle biosensor (MS) using a polycarprolactone micrnoeedle surface-modified with poly(3,4-ethylenedioxythiophene) (PEDOT) and complexed with hemin molecules. MS demonstrated high carrier mobility for real-time electrical read-out of nitric oxide (NO) signals with high sensitivity and selectivity which is appropriate to detect micromolar concentrations of NO in physiopathological conditions. MS rapidly distinguished the NO concentration difference between melanoma and normal tissues. In vivo application of the MS fabricated on endomicroscopy provided a powerful tool to identify carcinogenesis in colon cancer mice model by imaging of suspicious lesions and electrical detection of NO released by inflammation associated cancer progression. This dual diagnostic system of MS and endomicroscopy can be a new platform for facile and accurate detection of cancer in various biomedical applications. |
| 저자 |
금도희, 한세광, 정호상, 왕태준, 신명화, 김은영, 김기현, 안지완
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| 소속 |
POSTECH |
| 키워드 |
Microneedle; PEDOT; Nitric oxide; Biosensor; Cancer diagnosis
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| E-Mail |
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