| 초록 |
Herein, we report a facile approach to control the rheological properties of hyaluronic acid (HA) solutions by using the interchain association of electrostatically attractive polymeric micelles (APMs). The incorporation of the APMs into a gel-type HA solution not only readily transitioned the viscous flow to elastic flow but also easily led to the deformation of the gel microstructure in response to the shear rate, which is comparable to the case of a linear HA solution. We identified that the unique rheological behavior of the gel-type HA solutions stemmed from the APM-mediated particulate crosslinking. Finally, we demonstrated that the fine tuning of the interchain association by manipulation of the electrostatic interactions between APMs and HA molecules enabled the diversification of the rheological properties of HA solutions, making this system a promising hydrogel rheology controller. |
