| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
A pH-Activatable Doxorubicin-Loaded MnCO3 Nanoparticle for Theranostic Applications |
| 초록 |
Theranostic nanoparticles equipped with the dual functions of the simultaneous diagnosis and treatment of disease have received great interest in recent years. We aim to develop a theranostic agent based on doxorubicin (DOX)-loaded MnCO3 nanoparticles (DOX-MnCO3 NPs) that can generate CO2 bubbles and Mn2+ ions for US imaging and T1 imaging, respectively, and simultaneously release DOX for cancer treatment. At physiological pH (7.4), the DOX-MnCO3 NPs would not show noticeable US and T1 MR contrast signals. In contrast, at tumoral pH (6.4), they may generate strong echogenic signals due to CO2 bubble generation and T1 signals caused by the release of Mn2+ ions. Moreover, at tumoral pH, the DOX-MnCO3 NPs would effectively release DOX for cancer treatment. These pH-activatable theranostic agents may serve as novel theranostic nanoparticles with wide applicability for improved diagnostic and therapeutic activity for various cancers. |
| 저자 |
김기덕, 김다은, 이재원, 이홍재, 정서영, 이상천
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| 소속 |
경희대 |
| 키워드 |
US imaging; MRI; Manganese carbonate
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| E-Mail |
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