| 초록 |
Multimodal imaging of cancers holds promise in providing more accurate and precise diagnosis of cancers. In this work, we describe Gd2O3 nanoparticle-loaded CaCO3 mineralized nanoparticles (Gd2O3-MNPs) that can generate CO2 bubbles and trigger the release of Gd2O3 nanoparticles in response to acidic tumor pH. The CO2 bubbles and released Gd2O3 nanoparticles can serve as contrast agents for tumoral ultrasound (US) and magnetic resonance (MR) imaging, respectively. At physiological pH (7.4), the Gd2O3-MNPs showed no noticeable contrast signals under an US field. In contrast, at tumoral pH (6.4), there were strong echogenic signals due to CO2 bubbles generation by the dissolution of CaCO3 minerals. In addition, at tumoral pH (6.4), the Gd2O3-MNPs would effectively release Gd2O3 nanoparticles into the aqueous environment, resulting in a strong MR contrast enhancement. This multimodal contrast imaging agent might serve as a core element in diagnosis for various solid tumors. |
