| 초록 |
In the pharmaceutical industry, improving drug properties by using the crystal engineering has been regarded as an important strategy. For co-crystallization, materials of low molecular weights like nicotinamide and saccharin have been used to control the properties. However, these materials are not preferable as excipients in drug formulations. In here, polymers considered as safe were used to engineer the properties of natural polyphenols, which are well known for their anti-oxidant property and bioavailability. Polyphenols can be used for preserving human mesenchymal stem cells (hMSCs) from oxidative stress. By using a cooling crystallization method in presence of polymers, the polymer-directed crystallization of catechin was performed: A solution of catechin and polymer was cooled until catechin crystal separated. The polymer-directed crystallization method could be used for controlling polyphenol properties, and such changes could affect the release behaivor of polyphenols. |
