| 학회 | 한국화학공학회 |
| 학술대회 | 2006년 봄 (04/20 ~ 04/21, 대구 인터불고 호텔) |
| 권호 | 12권 1호, p.418 |
| 발표분야 | 생물화공 |
| 제목 | Enhanced production of anti-cancer drug epothilones by lactose and sodium propionate in Sorangium cellulosum cultures |
| 초록 | We investigated effect of lactose on epothilones production. Although lactose has not effect on cell-growth, it has effect on epothilones production. In comparison with control fermentation, total epothilones production was increased when lactose was added at the death phase. However, epothilones B/A ratio was decreased. Therefore, we added sodium propionate to the culture which is a precursor of methylmalonyl- CoA to increase epothilones B/A ratio. As a result, epothilones B/A ratio improve compared to control fermention. A final result, we confirmed that epothilones production was increased using lactose and epothilones B/A ratio was increased by sodium propionate. |
| 저자 | 박수정, 박상우, 심상준 |
| 소속 | 성균관대 |
| 키워드 | Sorangium cellulosum; lactose; sodium propionate |
| 원문파일 | 초록 보기 |
