| 초록 |
Recently, the combination of two or more imaging modalities has often been required to improve the diagnostic performance. Herein, we developed Gd2O3 nanoparticle-loaded calcium carbonate (CaCO3) mineralized nanoparticles (Gd2O3-MNPs) that can generate CO2 bubbles and trigger the release of Gd2O3 nanoparticles in response to tumoral acidic pH. The CO2 bubbles and released Gd2O3 nanoparticles can serve as contrast agents for tumoral ultrasound (US) and magnetic resonance (MR) imaging, respectively. At physiological pH (7.4), the Gd2O3-MNPs showed no noticeable US contrast signals. In contrast, at tumoral pH (6.4), there were strong echogenic signals due to CO2 bubbles generation by the dissolution of CaCO3 minerals. In addition, at tumoral pH (6.4), the Gd2O3-MNPs would effectively release Gd2O3 nanoparticles into the aqueous environment, resulting in a strong MR contrast enhancement. These Gd2O3-MNPs might serve as a promising contrast agent for US and MR imaging of various tumors. |
