| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.189 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Neuronal Differentiation of Adult Rat Bone Marrow Derived Stem Cells |
| 초록 | Stem cells are undifferentiated cells that displaying a high degree of self-renewal and differentiation potential and can be isolated from a mammalian tissues and organs. Especially, bone marrow stromal cells (BMSCs) are multipotent stem cells that can be differentiated into mesenchymal cell types such as chondrocytes, osteoblasts, adipocytes, and muscle cells by controlling cytokines in culture medium. In this study, we report that adult rat bone marrow stem cells can be induced to differentiate into neurons, potentially their usefulness in the treatment of neuronal disease. It was observed that cytoplasm in the flat rat bone marrow stem cells retracted towards the nucleus, forming a contracted multipolar cell body and process-like extensions peripherally. Also, cells expressed the neuronal marker NSE and NF. In conclusion, these results were evidence of neuronal differentiation from rat bone marrow stem cells. Acknowledgement : This work was supported by KMOICE (N11-A08-1402-05-1-3) |
| 저자 | 김은정1, 송지희1, 장지욱2, 강길선1, 이일우3, 이해방2 |
| 소속 | 1전북대, 2한국화학(연), 3가톨릭의대 신경외과 |
| 키워드 | BMSCs; Neuronal differentiation; NSE; NF |
