화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO))
권호 40권 2호
발표분야 의료용 고분자 부문위원회 II
제목 Controlled Release of Tamsulosin Using Triple Layer by Wet Granulation
초록 Tamsulosin(TS) is used in the treatment of difficult urination, a common symptom of enlarged prostate. In this study, TS was used as model drugs for the complex formulation as triple layer. TS extended layer was prepared as a wet granulation method to delay the solubility and LF immediate layer was prepared by physical mixture. Characterizations of the prepared wet granulation and physical mixture were analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), x-ray diffractometer (XRD) and differential scanning calorimeter (DSC). The in vitro drug release behavior of were also evaluated in intestinal juice (pH 6.8). This study suggests the complex formulation with the extended release layer and the immediate release layer can be suitable design for controlled release of TS. This research was supported by the Brain Korea 21 PLUS Project, NRF-2012M3A9C6050204, and Bio-industry Technology Development Program (KMIAFF, 112007-05-2-SB010).
저자 강길선, 이동원, 정현기, 이진표, 이원택
소속 전북대
키워드 Tamsulosin (TS); wet granulation; physical mixture; triple layer
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