| 학회 | 한국화학공학회 |
| 학술대회 | 2008년 봄 (04/23 ~ 04/25, 제주ICC) |
| 권호 | 14권 1호, p.351 |
| 발표분야 | 분리기술 |
| 제목 | Separation simulation of L-ribose and L-arabinose in 3-zone SMB (simulated moving bed) chromatography |
| 초록 | The use of L-carbohydrates and their corresponding nucleosides in medicinal application has greatly increased. For example L-ribose has been much in demand as the starting material for curing hepatitis B. SMB was invented by UOP in the early 1960s, and the SMB utilized the movement of ports or columns to mimic a counter-current movement of liquid and solid phase. The classical closed-loop 4-zone SMB approach reduces solvent consumption, but there can be occurred a risk of cross-contamination or mechanical demage in lines due to high pressure. In the open-loop 3-zone SMB, the recycle line of eluent be removed and the SMB consumes more solvent. However it can reduce the risk of cross-contamination or mechanical demage compared to the 4-zone SMB. In this study, we carried out simulations of the separation of L-ribose and L-arabinose in 3-zone SMB for the operating points in the so-called m2-m3 plane from triangle theory using Aspen chromatography. Acknowledgement This research was supported by Korea Energy Management Corporation as well as the BSEP ERC of Inha University. |
| 저자 | 전영주, 김인호 |
| 소속 | 충남대 |
| 키워드 | 3zone SMB; L-ribose; Aspen chromatography |
| 원문파일 | 초록 보기 |
