| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Novel kraft lignin-gelatin hydrogel for suppressing over-expressed reactive oxygen species to treat diabetic ulcer |
| 초록 |
Diabetic ulcer is one of the most common complications for patients with diabetes. It is difficult to treat since high blood sugar increases blood viscosity, which leads to insufficient nutrient supply towards nerves within the defect site. Specifically, over-expressed reactive oxygen species (ROS) accelerates advanced glycation end products (AGEs) by affecting glucose level, leading to blood supply disorders and chronic skin disease. In this study, a novel kraft lignin based antioxidant hydrogel was fabricated. Kraft lignin was introduced to gelatin matrix (Klig-Gel) and cross-linked via epoxidation. The chemical structure of kraft lignin chelates ferrous iron (Fe2+), which is the main factor that increases ROS expression though the Fenton reaction. Klig-Gel hydrogel was able relieve oxidative stress and inhibit over-oxidation process effectively. Therefore, it shows possibility to normalize the balance between natural antioxidant and ROS, and enhance diabetic ulcer treatment. |
| 저자 |
김별하나1, 김영2, 정영미3, 고원건1, 정지홍4
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| 소속 |
1연세대, 2서울대, 3KIST, 4한국과학기술(연) |
| 키워드 |
Kraft Lignin; ROS; Chronic Wound Healing; Functional Hydrogel
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| E-Mail |
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