| 학회 | 한국화학공학회 |
| 학술대회 | 2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 | 13권 2호, p.1514 |
| 발표분야 | 공정시스템 |
| 제목 | Identification of the most plausible metabolic pathways in perturbed metabolic systems |
| 초록 | A synergetical implementation of accelerated branch-and-bound method and graph-theoretic method based on P-graphs to metabolic pathway networks tends to yield the most plausible stoichiometrically feasible pathways. An effective approach has been proposed based on an available accelerated branch-and-bound to rank the growth rate maximization and minimization of the set of genetic perturbations of such stochiometrically feasible pathways. The approach’s efficacy has been ascertained by applying to various biological systems. Acknowledgement This work was supported by the Korean Systems Biology Research Program (M10309020000-03B5002-00000) of the Ministry of Science and Technology and by the BK21 project. Further supports from LG Chemicals Chair Professorship and IBM-SUR program are greatly appreciated. |
| 저자 | 윤좌문1, 김 영2, 이상엽1, 박선원3 |
| 소속 | 1한국과학기술원 생명화학공학과, 2초미세화학공정 시스템센터 / 한국과학기술원 바이오시스템학과 생물정보연구센터, 3초미세화학공정 시스템센터 |
| 키워드 | metabolic pathway analysis; p-graphs; steady state condition |
| 원문파일 | 초록 보기 |
