| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and Biological Evaluation of DNA-Assembled Polyamidoamine (PAMAM) Dendrimer Nanoclusters |
| 초록 |
Major challenges for the application of polymers to biology and medicine especially in the cancer treatment include biocompatibility, well-defined molecular characteristics, and customized therapeutics because of great need for efficient delivery of therapeutic agents and various molecular alterations (mutation) even among individual patients. Herein a unique molecular platform based on the DNA-directed assembly of dendritic polymers for the delivery of different agents to cancer cells is presented. DNA-assembled imaging and targeting polyamidoamine (PAMAM) dendrimers specifically target KB cells over-expressing folate receptors and internalize into cells. This DNA-directed approach could allow for Mix-and-Match strategy for drug delivery of different drugs with different targeting and imaging agents and provide a basis for production of nanostructured and mesoscopic architectures from organic and inorganic materials in the field of nanoscience and newly emerging nanobiotechnology. |
| 저자 |
최영선1, James R. Baker Jr.2
|
| 소속 |
1한국파스퇴르(연), 2Univ. of Michigan |
| 키워드 |
Dendrimer; DNA; Cancer targeting; Self-assembly
|
| E-Mail |
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