| 학회 |
한국화학공학회 |
| 학술대회 |
2010년 가을 (10/21 ~ 10/22, 대전컨벤션센터) |
| 권호 |
16권 2호, p.2127 |
| 발표분야 |
재료 |
| 제목 |
Detection of epidermal growth factor receptor using fluorescence resonance energy transfer |
| 초록 |
We have detected mutations in the EGFR(Epidermal Growth Factor Receptor) using FRET(Fluorescence Resonance Energy Transfer) phenomenon between CdSe quantum dots and gold nanoparticles. We synthesized chemically modified two types of CdSe quantum dots and gold nanoparticles using four different types of probe DNAs that are perfect complementary to the mutation in exon 19 and exon 21 of EGFR. The FRET phenomenon between green/yellow CdSe quantum dots and gold nanoparticles was shown to occur for the Exon 19 or 21 with mutation. To observe FRET phenomenon, we use the photoluminescence spectroscopy and transmission electron microscopy. |
| 저자 |
이호섭1, 최동철1, 이창하1, 윤경아2, 이강택1
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| 소속 |
1연세대, 2국립암센터 |
| 키워드 |
gold nanoparticle; quantum dot; FRET; EGFR
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| E-Mail |
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| 원문파일 |
초록 보기 |
