| 초록 |
Photodynamic therapy (PDT) utilizes a combination of a photosensitizer (PS) with preferential uptake by tumor cells and visible light. Upon light activation of the PS at a specific wavelength and in the presence of oxygen, reactive oxygen species (ROS) are generated, which leads to tumor destruction. Singlet oxygen or free radicals cause cell death and necrosis of tumor components, with minimal damage to the adjacent healthy tissue. However, PS are limited in application as a result of prolonged cutaneous PS, poor water-solubility and inadequate selectivity. To overcome limit, we used the peptide 18-4 (p18-4) which has an ability to target onto breast cancer cells. We designed tumor targeted PS using octamaleicacid POSS (POSS), p18-4 and chlorin e6 (ce6). We synthesized nanoparticles of POSS and ce6 having a novel stable engineered peptide ligand, namely p18-4, that binds specifically to breast cancer cell line MDA-MB-231 on its surface. As a result, we confirmed effect of PPC. |
