화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2008년 가을 (10/23 ~ 10/24, 부산 BEXCO)
권호 14권 2호, p.2310
발표분야 고분자
제목 Biocompatible Polymer Nanoparticles-Based Bimodal Imaging Contrast Agents for the Labeling and Tracking of Immunotherapeutic Cells
초록 Here, we developed biocompatible polymer-based nanoprobes for both magnetic resonance imaging (MRI) and near-infrared (NIR) fluorescence imaging. With the help of dual-functional PLGA nanoparticles, the migration of dendritic cells (DC) via lymphatic drainage was monitored through real-time NIR fluorescence imaging, and the homing of dendritic cells into lymph nodes through noninvasive MRI techniques was also accomplished. The biocompatible polymer-based bimodal imaging contrast agents are expected to be used for the effective trafficking of DC to the lymph nodes of patients, which is highly required for the efficient DC-based immunotherapy of cancers.
저자 임용택, 정봉현
소속 한국생명공학(연)
키워드 Biocompatible Polymer; Nanoparticles; Immunotherapeutic Cells
E-Mail chungbh@kribb.re.kr
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