| 학회 | 한국공업화학회 |
| 학술대회 | 2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 | 19권 1호 |
| 발표분야 | (콜로이드계면화학) 나노소재 기술에 있어서 콜로이드 공학의 응용 (중앙대 임경희 교수 정년 퇴임 기념) |
| 제목 | Compact and functional nanocrystals for biological applications |
| 초록 | We have developed magnetic nanoparticles (MPs) and quantum dots (QDs) with small hydrodynamic radius, containing various functional groups that readily compatible for conjugation to bio-molecules. The main advantage of making smallest MPs as possible is that we expect to see the enhancement in many properties including increase of diffusion rate and decrease of steric hindrance to bio-molecule conjugation when compared to the larger MPs. To achieve this goal, we’d like to design new biocompatible lidands, modify the surface of nanomaterials using newly designed molecules by ligand exchange method, and finally test the cell viability of those new materials by incubating in the cell. One example is 1,2-enediol ligand that was inspired by bio organism existing in the nature, in order to overcome problems that surface of iron oxide nanocrystals was etched and crashed out together. When we characterized the surface engineered colloidal nanocrystals using DLS and TEM, the resulting nanocrystals shows good chemical stability as well as magnetic property. Recently, the zwitterionic polymers have attracted significant interests from scientists due to their characteristic hydrophilicity and nonspecific adsorption to biomolecules. For the stable dispersion of QDs, we synthesized a new type of zwitterionic polymer ligand to render QD surface adsorptive, thus developed a diagnostic agent which can retain their dimension stability from protein coagulation. The zwitterionic polymer is a random copolymer synthesized by the RAFT polymerization with a narrow molecular weight distribution. The histamine group of the zwitterionic polymer can act as binding site with QD surface while the exterior amine (e.g. 3-(methacryloylamino)propyl)-dimethyl(3-sulfopropyl)ammonium hydroxide) group can show an excellent stability in aqueous solutions. In addition, a folate group was bonded with the derived amine group on QD for targeting to a specific organ. Therefore, the high photostability and the high amine functionality were confirmed by targeting the QD with folate group to Hela cancer cell with folate receptor. |
| 저자 | 박종남 |
| 소속 | UNIST |
| 키워드 | Magnetic nanoparticles; Quantum dots; zwitterionic polymers |
