| 학회 |
한국화학공학회 |
| 학술대회 |
2013년 가을 (10/23 ~ 10/25, 대구 EXCO) |
| 권호 |
19권 2호, p.1179 |
| 발표분야 |
고분자 |
| 제목 |
Polysuccinimide graft copolymer encapsulated magnetites conjugated with Cytotoxic T-Lymphocyte |
| 초록 |
In this research, a series of polysuccinimide(PSI) graft copolymer was prepared by grafting O-(2-aminoethyl)-O'-methylpoly(ethylene glycol) 5000(MPEG). The synthesized polysuccinimide derivatives were coated on iron oxide magnetic nanoparticle for magnetic resonance(MR) imaging materials. Maleimide was grafed on polymer coated iron oxide nanoparticle for chemical bonding between T-cell and PSI, respectively. The chemical structure and degree of substitution(DS) of prepared polymer were analyzed by FT-IR and 1H-NMR spectroscopy. And size of polymer and iron oxide nanoparticle was confirmed using transmission electron microscopy(TEM) and dynamic light scattering(DLS). This polyaspartamide derivatives encapsulating magnetites is applicable for cancer diagnosis and treatment. |
| 저자 |
김민선, 김덕준
|
| 소속 |
성균관대 |
| 키워드 |
polysuccinimide; magnetite; nano aggregate; T-cell
|
| E-Mail |
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| 원문파일 |
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