화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU))
권호 23권 2호
발표분야 (생체재료) 치료용 생체재료
제목 Development of cardiac toxicity evaluation platforms for new drug development
초록 A number of clinically used drugs can cause side effects on the functions of the heart, such as torsades de pointes (TdP), and lead to withdraw from the pharmaceutical market in clinical use. Therefore, the nonclinical cardiotoxicity testing has become an important part of the regulatory procedure, such as electrocardiogram (ECG), action potential and ion currents. Despite all the efforts to establish and to validate preclinical models, none of the preclinical in vitro and in vivo methods have been proven to be fully predictive for QT prolongation and for torsadogenic potential because of interspecies differences. In addition to the differences between species, ethical concerns about the use of laboratory animals and investing a lot of time and money act as obstacles to the development of new drugs, a new paradigm of nonclinical cardiotoxicity testing is required. Therefore, I would like to introduce the development of alternative toxicity models in our laboratory.
저자 김기석
소속 안전성평가(연)
키워드 cardiotoxicity; alternative toxicology; new drugs development
E-Mail idkks@kitox.re.kr