| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Simple fabrication of silver hybridized porous chitosan-based patch for transdermal drug-delivery system |
| 초록 |
To improve the physiochemical properties of bio-patch materials, silver compounds of various concentrations were synthesized in chitosan solution and formed to silver hybridized porous chitosan structures. We examined various properties such as morphology, crystallization intensity, mechanical strength, hydrophilic ratio and drug-delivery efficiency. We ascertained that it was optimal to combine silver nitrate of 3%, chitosan of 1% (molecular weight ＜1000 kDa), and sodium borohydride of 0.003% for achieving high mechanical strength and drug-delivery efficiency. Drug release rate and hydrophilic ratio was increased due to silver concentration increment. Further, the initial drug release of the silver hybridized porous chitosan patch was approximately 1.5 times faster than that of the chitosan patch as control. These results indicate that silver hybridized porous chitosan patch can be widely used as sterilizing transdermal drug-delivery system (TDDS) in various fields. |
| 저자 |
임진익, 김주승, Le Thi Kim Tram, 김응석, 이우걸
|
| 소속 |
단국대 |
| 키워드 |
drug-delivery system; chitosan
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| E-Mail |
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