| 초록 |
Chiral intermediates such chiral epoxides and diols are important synthons for the synthesis of chiral pharmaceuticals. Epoxide hydrolases (EHs) can be used for preparing chiral epoxides and the corresponding vicinal diols. Chiral vicinal (R)-1,2-phenylethanediol could be obtained with yield more than 50% by EHs-mediated enantioselective biohydrolysis. Effects of surfactant addition and reaction temperature on enantiopurity and yield were investigated for single or two EHs-catalyzed enantioselective biohydrolysis reactions. Acknowledgment: This work was supported by the Marine and Extreme Genome Research Center Program, Ministry of Marine Affairs and Fisheries, Republic of Korea. |
