| 학회 |
한국공업화학회 |
| 학술대회 |
2011년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터) |
| 권호 |
15권 1호 |
| 발표분야 |
정밀화학 |
| 제목 |
Synthesis of Methotrexate grafted Low Molecular water soluble chitosan with Metoxy poly ethylene glycol and Biotin |
| 초록 |
The Biotin-PEG-Low molecular water soluble chitosan-Methotrexate (BPLMMTX) was synthesized by reaction with LMWSC-MTX (LMMTX) and Metoxy Poly(Ethylene glycol) (mPEG). The structure was prepared by chemical reaction with Biotin, mPEG and LMMTX for Targeted polymeric drug delivery system. The structure was investigated by Fourier transform infrared (FT-IR), and ¹H Nuclear magnetic resonance (¹H-NMR), Particle formation was confirmed to become by Transmission electron microscopy (TEM,), Electrophoretic LS spectrophotometer (ELS-8000). These results indicate that the efficacy of MTX against tumor cells can be increased by this targeting method. |
| 저자 |
김태훈, 박준규, 남정표, 김원석, 최창용, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
LMWSC; mPEG; Methotrexate; Biotin; Polymeric drug.
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| E-Mail |
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