| 학회 |
한국공업화학회 |
| 학술대회 |
2011년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터) |
| 권호 |
15권 1호 |
| 발표분야 |
정밀화학 |
| 제목 |
Synthesis of Chitosan Nanoparticles improved by PEGylation with Targeting Peptide for Gene carrier |
| 초록 |
In this study we conjugated the cyclic dimeric RGD peptide, E-[c(RGDfK)2 with difunctional polyethylene glycol (PEG) into the cationic polymer, LMWSC (Low molecular weight water soluble chitosan). Tumor growth was αvβ3 integrin-binding related to angiogenesis dependent. Targeted polymeric gene delivery system, LMWSC-PEG-RGD (LMPR), was developed by incorporating the αvβ3 integrin-binding. We synthesized LMWSC-PEG-RGD conjugate and the physicochemical properties of the LMPR were investigated by using 1H-NMR, Dynamic light scattering and Transmission Electron Microscope (TEM). The LMPR Nanoparticle was investigated to gene carrier. |
| 저자 |
홍락준, 박준규, 김원석, 최창용, 나재운, 장미경
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| 소속 |
순천대 |
| 키워드 |
LMWSC; peptide; Target delivery; gene; cancer therapy
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| E-Mail |
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