| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Synthesis of PEG-b-Poly(L-lysine-co-L-Phenylalanine)s Conjugated with L-Arginine as a Non-viral Gene Delivery Vector |
| 초록 |
Natural and synthetic polycations displaying non-pathogenic and non-immunogenic properties have been employed as non-viral vectors for gene delivery due to the safety concerns. The main obstacle in gene therapy is the development of efficient, non-toxic delivery carriers, which effectively transport DNA inside the cell nucleus of the target. Lysine based amino acid copolymers containing 30 molar % of phenylalanine residues (PK7F3) were prepared with α-methoxy-ω-aminopoly(ethylene glycol) block at one end. Primary amino groups in the side chain of lysine residues were conjugated with L-arginine in almost quantitative yields. Obtained copolymers were applied as a gene delivery carrier and the selective targeted delivery to the neuron cells were tested with the introduction of a neuron cell specific ligands by physical mixing with the copolymers. |
| 저자 |
임미정1, 안철희1, 이민형2
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| 소속 |
1서울대, 2한양대 |
| 키워드 |
gene delivery; PEG-b-Poly(L-lysine-co-L-Phenylalanine)s Conjugated with L-Arginine
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| E-Mail |
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