| 초록 |
Nano-sized self-assemblies formed with amphiphilic block or graft copolymers have been extensively studied for targeted drug delivery of diagnostic and therapeutic molecules. It is common to modify the self-assemblies’ surface by varying the number of targeting ligands for enhancing their targeting efficiency. Recently, several studies have reported that the shape of a particle could be one of the significant factors in modulating the particle’s targeting capability. This study presents a novel strategy to prepare polyaspartamides self-assemblies with high aspect ratio by varying packing structure. Furthermore, porphyrin provides the versatile building block for tailored materials properties, and oxygen binding capability for sensing and delivery. Therefore, we developed the nano-bubbles decorated with porphyrin-conjugated polyaspartamide for a molecular ultrasound imaging with various biomedical modalities. |
