| 초록 |
A group of polymers shows the chemical structure in response to pH change. Polymers containing imine bonds, hydrazine bonds, and many other pH-responsive bonds are utilized as smart materials in the biomedical field. In this study, we use an acid anhydride with a fixed α,β-bond for the development of pH-responsive polymer. The polymers with such anhydride bonds can easily react with amines to form acid amide bonds and the bonds are degradable in response to pH change. At neutral or basic pH, the bonds are quite stable but at mildly acidic pH conditions, they are rapidly degraded. These polymers can be applied to develop materials containing pH-responsive moieties with high density for the drug delivery system. |
