| 학회 | 한국공업화학회 |
| 학술대회 | 2014년 가을 (11/12 ~ 11/14, 엑스코(대구)) |
| 권호 | 18권 2호 |
| 발표분야 | 정밀화학-포스터 |
| 제목 | Environmentally friend process for paracetamol |
| 초록 | Paracetamol, N-acetyl-para-aminophenol, is a common analgesic for headache or other minor pains. Since it was first introduced to the pharmacological market as a prescribed analgesics and antipyretic drug for children in 1950s, more than 600 different over-the-counter and prescription medicines containing paracetamol have been distributed worldwide. Despite of its prevalent use, the production of paracetamol is not much deviated from the original synthetic route where para-aminophenol is synthesized as a key intermediate. In order to overcome the chronic drawbacks of the conventional synthetic method for paracetamol including harsh reaction conditions and chemo-and region- selectivity issues, an environmentally friend and regioselective synthetic procedure has been developed from halobenzenes via the metal catalyzed amidation reaction and the followed hydroxylation reaction. |
| 저자 | 서영란, 김영규, 고무현, 강은실, 이윤재 |
| 소속 | 서울대 |
| 키워드 | paracetamol; N-acetyl-para-aminophenol; analgesic |
