| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
[생체재료] 포스트 코로나 시대를 위한 바이오소재 기술 |
| 제목 |
Inflammation-responsive hydrogel for local-immunomodulation via epigenetic control of macrophages in wound healing |
| 초록 |
Bioresponsive hydrogels are promising drug carriers as actively responding to the disease environment for optimal therapeutic efficacy. In this study, the inflammation-responsive hydrogel was developed to achieve effective drug delivery at the inflammatory site. Peptide-based linkers which could be cleavable by cathepsins were introduced to modified alginate to deliver the drug in the inflammation state. Inflammation-responsive hydrogel loading with JQ1 responded to M1 polarized macrophages rather than the resting state of macrophages and excessively released JQ1 suppressed inflammation. Ultimately, our system developed in this study can potentially be used in the wide biomedical application. |
| 저자 |
김혜림1, 국윤민2, 김상헌2, 이강원2, 오승자2
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| 소속 |
1서울대, 2한국과학기술(연) |
| 키워드 |
면역환경 감응성 하이드로젤; 국소면역조절; 후성유전자조절; 조직재생
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| E-Mail |
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