| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Thermo-sensitive Injectable N-hexanoyl Glycol Chitosan Hydrogel for Treatment of Degenerative Disc Disease |
| 초록 |
The use of intradically injectable hydrogel formulations have been suggested as a promising strategy for the treatment of degenerative disc disease that can both restore the biomechanical function and reduce the low back pain. Here, a new thermogelling polymer, N-hexanoyl glycol chitosan (HGC) was fabricated with tunable thermo-sensitivity and high stability. The physicochemical properties of HGC were characterized by 1H NMR, FT-IR and rheometer. The sol-gel transition temperature of HGC could be controlled in a range of 23~56 ºС. In vivo toxicological results confirmed HGC hydrogel had no adverse effects in the rat moldel. HGC hydrogel was injected into the degenerated IVD ex vivo model and evaluated by macroscopic observation, micro-computed tomography examination and histological analysis. The defected IVD was fully filled with HGC hydrogel, which was stable even at 28 days. These results suggested HGC hydrogel has great potential for percutaneous treatment of disc herniation. |
| 저자 |
허강무1, 권보선2, 강선웅3, 조익성1, 조명옥1, 박성걸3, 심혜은3, 이정정2
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| 소속 |
1충남대, 2우리들휴브레인(주), 3안전성평가(연) |
| 키워드 |
Thermo-sensitive hydrogel; Injectable hydrogel; Glycol chitosan; N-hexanoyl glycol chitosan; Disc herniation
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| E-Mail |
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