| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Thrombin Activatable CT/NIRF Dual Imaging Probe Based on Gold Nanoparticles |
| 초록 |
Gold nanoparticles (AuNPs) are a unique material because of their controllable morphology, low cytotoxicity, surface plasma resonance effect and high X-ray absorption. For these reasons, AuNPs have attracted scientist’s attention that developed AuNPs as an imaging probe. In this study, we developed thrombin activatable CT/NIRF imaging probe which can detect thrombosis in the blood stream. The particles were coated with silica layer to have stability and biocompatibility in human body. Then thrombin activatable peptide conjugated dye (Thr-dye) was conjugated to the nanoparticle surface. When the probe interact with thrombin, which it is well known as serine protease, the enzyme cleaves the peptide and dequenches NIRF dye which makes detecting thrombosis possible. These feasibilities of biocompatible AuNPs as CT/NIRF dual imaging probe were showed promising results for detecting thrombosis. |
| 저자 |
권성필1, 안철희2, 권익찬, 김정연1, 김동억2, 김광명3
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| 소속 |
1Department of Materials Science and Engineering, 2College of Engineering, 3Biomedical Research Center |
| 키워드 |
Gold nanoparticle; dual imaging; optical; CT imaging
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| E-Mail |
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