| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of Preparation Conditions on Release Behavior of Ropinirole HCl-loaded Polyoxalate Microspheres |
| 초록 |
Ropinirole HCl is used in the treatment of Parkinsons's disease and Restless Legs Syndrome (RLS),ect. Ropinirole HCl-loaded Polyoxalate (POX) microspheres were prepared by W1/O/W2 and O/W1,2 solvent evaporation method for sustained release. This study was investigated the release behavior according to the kind of solvent and preparation conditions. Ropinirole HCl-loaded POX microspheres by W1/O/W2 and O/W1,2 , solvent evaporation method had smooth surfaces. The microsphere was characterized on the surface, the cross-section morphology and the behavior of Ropinirole HCl release for 15 days by SEM and HPLC. The analysis of crystallization was analyzed to use XRD, DSC and FT-IR. In this study, the results showed that the release behaviors can be controlled by various of preparation conditions. This research was supported by MIFAFF (112007-05-1-SB010) and MEST (2012M3A9C6050203). |
| 저자 |
이천중, 김경희, 오승창, 조선아, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Sustained release; Ropinirole-HCl; Polyoxalate (POX); Solvent evaporation method
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| E-Mail |
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