| 초록 |
Protein based hydrogels are considered as attractive biomedical materials because of their excellent biocompatibility and biodegradation. Among them, recombinant proteins made up of spherical protein molecules and intrinsically disordered protein (IDP) molecules are good materials to form hydrogel because they can be made by modifying the genetic level and structurally stable. Also, they can be used to mimic extracellular matrix (ECM) since they are used as injectable hydrogel. Here, we suggest that recombinant protein which mimic ECM in vivo. In this study, a series of designed protein particles are developed, which named for FRCs, by genetically conjugating IDP to the surface of ferritin proteins. For characterization of the FRCs, experiments for SDS PAGE, Western blotting, TEM were performed. Then, from SEM analysis, it is confirmed that FRCs have sufficient pore size to serve as ECM. Therefore, with this results, we expect that FRCs based hydrogels also mimic ECM in vivo. |
