| 초록 |
Microneedle (MN) has been desired as a therapeutic tool which allow transdermal administration of various drugs with easily and painlessly. In this study, nano-micelle generating dissolvable MN was designed by a biocompatible amphiphilic tri-block copolymer. When fabricating with doxorubicin (DOX) in the MN, the hydrophobic anticancer drug can be dissolved in an aqueous medium by entrapped in nano-micelles generated by dissolution of the MN. The intratumoral administration of the DOX-encapsulated MN can significantly inhibit the growth of melanoma in a mouse skin cancer model. Furthermore, owing to its small size (< 50 nm), the nano-micelle can efficiently migrate to the sentinel lymph nodes, killing the metastatic skin cancer cells. Therefore, the use of locally application of MN can be considered as a promising therapeutic device for the inhibition of metastatic skin cancer. |
