| 초록 |
Although there is no problem just by kicking a pocket after the bladder is removed after bladder cancer surgery, artificial bladder is expected to be needed as people's lives improve. Silicone known as useful properties for biomaterial is widely used for artificial bladder. However, if the silicon based artificial bladder is not pre-treated on the surface, calcification may occur due to urine. Therefore, developing robust and long lasting-surface modification techniques for artificial bladders will be an important factor in preventing calcification occurring in artificial bladders. Hence, we modified silicone surface with dopamine conjugated hyaluronic acid(DA-HA) and polyacrlyic acid(PAA). The dopamine's amine group conjugated with HA which has anti calcification property and dopamine's catechol group was reacted on top of the silicon material. In case of PAA, Radical was generated on a PDMS by benzophenone, and a solution mixed with AA and Irgacure 2959 was added to form PAA hydrogel on the PDMS. The surface modified silicone showed that it reduced calcification comparing to bare silicon, which means stable for artificial bladder's material. |
