| 학회 |
한국화학공학회 |
| 학술대회 |
2022년 봄 (04/20 ~ 04/23, 제주국제컨벤션센터) |
| 권호 |
28권 1호, p.1244 |
| 발표분야 |
[주제 12] 화학공학일반(부문위원회 발표) |
| 제목 |
Effects of basic fibroblast growth factor combined with an injectable in situ crosslinked hyaluronic acid hydrogel for a dermal filler |
| 초록 |
Hyaluronic acid (HA) has been applied as a biomaterial for injectable dermal filler due to the unique viscoelastic property. Although HA derivatives are promising dermal filler materials, poor durability by degradation is the limitation. The chemical crosslinking of HA hydrogel is necessary to restrain the degradation rate. Herein, we present an injectable in situ HA hydrogel containing basic fibroblast growth factor (bFGF) crosslinked via a visible light-induced thiol-ene reaction which is triggered by riboflavin phosphate with blue light (BL) exposure. The mechanical property, matrix degradation and protein release of HA hydrogels were evaluated regarding SH-HA and MA-HA ratio. The HA hydrogels improve NIH/3T3 fibroblast proliferation and migration, and the bFGFs in HA hydrogel additionally induce the cell proliferation and scratch closure rate. In addition, the HA hydrogel precursor solution under a porcine skin forms hydrogel by transmitted BL through the skin, so the gelation can occur under the skin after injection. In conclusion, the in situ crosslinked HA hydrogel is a promising injectable and long-lasting dermal filler that can deliver therapeutic factors. |
| 저자 |
김도현1, 김혜원1, 안수정1, 박재욱1, 고원건1, 이현종2
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| 소속 |
1연세대, 2가천대 |
| 키워드 |
생물화공(Biochemical Engineering) |
| E-Mail |
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| 원문파일 |
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