| 초록 |
The demand for fat reduction has been rapidly increasing to date. Although liposuction remains the most popular method for the reduction of subcutaneous fat, this approach may cause severe side effects including pain. Here, we reported the preparation and characterization of poly(ethylene glycol) (PEG)-based micelles that can generate carbon dioxide gas as an adipocytolytic agent. PEG-based amphiphilic polymers containing the carbonate linkage were synthesized and used to form micelles. Structural changes in the PEG-based amphiphilic polymers significantly influenced the generation of carbon dioxide gas from the micelles. Nona-arginine peptide, a representative cell-penetrating peptide, was introduced to the surface of the micelles for effective intracellular delivery. This micelle system could have the potential as an adipocytolytic agent for reduction of localized fat deposit. |
