| 초록 |
To achieve on-demand drug delivery, we prepared an implantable pump acutated by static magnetic field (MDP). The device mainly consisted of a drug reservoir, cylindrical chamber and plunger made of poly (methyl methacrylate). The drug was pumped when an external magnetic field was applied and removed: the plunger was pulled upward and downward, respecively, to push the drug outward via the outlet formed at the bottom of the pump. When there is no external magnetic field, the heads of a cylindrical chamber and a plunger, made of magnets, were attached to close the outlet, therby no drug release. Therfore, in this work, we could vary the amount of delivered drug by controlling the number of outlets and acutations. When the pump was implanted in Sprague Dawley (SD) rats for 30 days, the drug could be detected in the blood plasma only when the pump was actuated. Therfore, we conclude that the MDP has a high potential for on-demand, pulsatile drug release. |
