| 초록 |
Among various wearable devices, a smart contact lens is especially noticeable for healthcare applications, because it can be used as an excellent interface between the human body and an electronic device. Here, we developed a smart contact lens for both continuous diabetic monitoring and diabetic retinopathy therapy. Smart contact lens could measure tear glucose levels as a non-invasive alternative to the conventional blood glucose tests and deliver drugs from gold coated reservoirs for the treatment of diabetic retinopathy. On the basis of these results, we also developed a smart NIR light emitting contact lens for the diabetic diagnosis and the treatment of diabetic retinopathy. The retinal vascular hyper-permeability induced by diabetic retinopathy in rabbits was reduced to the statistically significant level by simply wearing the NIR light emitting contact lens. Finally, we developed a smart contact lens to monitor and control the intraocular pressure (IOP) for the treatment of glaucoma. The IOP could be maintained in a controlled manner by the released drug in response to the measured IOP. |
