| 초록 |
Nano-particle systems usually present some degree of tumor targeting based on the EPR effect. Previously, we reported that Chitosan-functionalized, Pluronic-based nano-carriers also showed a good tumor targeting. However, like all other kinds of targeted nano-systems, they showed fluorescence signals from non-specific distribution of the nano-carriers, especially from liver. To overcome these background signals, we prepared the hydrocyanine-conjugated nano-carriers (Hydrocyanine-NC), thus they can detect reactive oxygen species (ROS) in tumor pathological site. The hydrocyanine labeling of nano-carriers resulted in almost complete disappearance of fluorescence signal from liver, and it produced strong fluorescence emission to monitor the target tumor site selectivity. Partial financial support by Basic Science Research Program, NRF, MEST, (R15-2008-006-02002-0 and 20100011952). |
