| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Multiomics based characterization of inhibition mechanism of methicillin-resistant Staphylococcus aureus by Lactobacillus isolates from infant stool |
| 초록 | As demands to control methicillin-resistant Staphylococcusaureus (MRSA) increase, approaches to inhibit the growth or to lower thevirulence using probiotics have been published. Nevertheless, it was reportedthat Lactobacillus species, one of the probiotic genera, haveantibacterial activity against MRSA, the molecular mechanism of anti-MRSA effectis unclear. In here, we screened the Lactobacillus strains with highMRSA inhibitory effect (L. gasseri HL20) and performed multiomics dataanalysis. As a results, it was observed that MRSA co-cultured with L.gasseri HL20 upregulate protein synthesis and downregulated various virulencefactors. In conclusion, multiomics approach revealed that the underlyingmechanism involved in anti-MRSA by lactobacillus was discovered. |
| 저자 | 조성현, 권지은, 박지현, 김예림, 김민규, 백지현, 권서영, 김윤곤 |
| 소속 | 숭실대 |
| 키워드 | MRSA; Lactobacillus; Multiomics; Inhibition |
