| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Multiomics approaches for the investigation of Clostridioides difficile inhibition mechanism by Bifidobacterium species |
| 초록 | Recently, the development of a newalternative treatment is required due to difficulty in treatment of Clostridioidesdifficile infection (CDI) and high recurrence rate. Althoughnew approaches using probiotic therapy have been reported for CDI treatment andprevention, the inhibition mechanisms of C.difficile by probiotics are unclear at the molecular level. In this study, five Bifidobacterium species were evaluatedthe C. difficile growth inhibitoryeffects. Then, the responses of C.difficile caused by B. longum were observed using proteomic andmetabolomic analysis. The multiomics data showed that proteins involved inproline-dependent regulation, protein synthesis, etc. were significantlychanged. In conclusion, we can observe metabolic changes involved in growth inhibition and toxin reduction effect ofprobiotics on C. difficile. |
| 저자 | 조성현, 권지은, 박지현, 김예림, 백지현, 김민규, 권서영, 김윤곤 |
| 소속 | 숭실대 |
| 키워드 | Clostridioides difficile; Probiotics; Multiomics |
