| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I (영어발표) |
| 제목 |
Biomecial applicationa of Curcumin for cancer therapy |
| 초록 |
Curcumin (CRC) has been widely used as a therapeutic agent for various drug delivery applications. We used curcumin as a drug delivery vehicle as well as therapeutic cancer agent. In the first part, we focused on the applicability of CRC as a drug delivery vehicle for doxorubicin (DOX) coated with poly-(ethylene glycol) (PEG) as an effective therapeutic strategy against multidrug-resistant cancer cells. The nanocomplexes were well localized within the resistant cancer cells inducing apoptosis and suppressed the tumor growth. In the second part, we developed novel hyaluronic acid cross-linked zein nanogels (HA-Zein NGs) to deliver the potential anticancer agent curcumin. The CRC encapsulated HA-Zein NGs were found to exert a specific toxicity against CD44 positive cancer cell (CT26 tumor cell) in vitro. The in vivo bio-distribution with a CT26 tumor model showed their high tumor accumulation thereby improved antitumor efficacy with a low dosage of CRC. |
| 저자 |
김유천 |
| 소속 |
한국과학기술원 |
| 키워드 |
Curcumin; Cancer therapy; Drug delivery
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| E-Mail |
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