| 초록 |
We designed amphiphile-stabilized nanocomposites consisting of a perfluoro interior with CdSe/ZnS quantum dots (QDs) and investigated correlations between the inner environment of nanostructures and the cytotoxicity of QDs. CdSe/ZnS QDs were perfluorinated via ligand exchange with 1H,1H,2H,2H-perfluorodecanethiol, and subsequently transferred to a water phase by Zonyl® FS-300 fluorosurfactants. A counterpart system was prepared, in parallel, as a conventional formulation with Pluoronic® F-127 passivating QDs whose ligands were exchanged with 1-dodecanethiol in advance. According to the quenching degree of QDs’ photoluminescence, perfluorinated nanocomposites revealed higher stability in serum, compared to that of Pluronic-stabilized particles. This result implies that the contact of water on the surface of QDs is more likely prohibited by perfluoro surroundings. Cytotoxicity of two systems was further investigated with analyses on optical properties and leaked ion concentration. |
