| 학회 |
한국화학공학회 |
| 학술대회 |
2018년 가을 (10/24 ~ 10/26, 대구 EXCO) |
| 권호 |
24권 2호, p.1449 |
| 발표분야 |
생물화공(Biochemical Engineering) |
| 제목 |
Bioinspired silica nanoparticle coating for titanium-based implants |
| 초록 |
Silica nanoparticles (SiNPs) have been utilized to construct bioactive nanostructures comprising surface topographic features and bioactivity that enhance the activity of bone cells onto titanium-based implants. However, there have been no previous attempt to create microrough surfaces based on SiNP nanostructures even though microroughness is established as a characteristic that provides beneficial effects in improving the biomechaical interlocking of titanium implants. Herein, we propose a protein-based SiNP coating as an osteopromotive surface functionalization approach to create microroughness on titanium implant surfaces. A bioengineered recombinant mussel adhesive protein fused with a silica precipitating R5 peptide (R5-MAP) enables to directly control the microroughness of the surface through the multilayer assembly of SiNP nanostructures under mild conditions. The assembled SiNP nanostructure significantly enhances the in vivo osteogenic cellular behaviors of preosteoblasts in a roughness-dependent manner and promotes the in vivo bone tissue formation on a titanium implant within a calvarial defect site. |
| 저자 |
김창섭 |
| 소속 |
영남대 |
| 키워드 |
생물화공 |
| E-Mail |
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| 원문파일 |
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