| 초록 |
Owing to their unique properties, mesenchymal stem cell (MSC)-derived exosomes have been actively studied for treatment of wide variety of diseases. However, it still remains challenging to improve the therapeutic outcomes of using exosomes to treat those diseases. Very small quantities of exosomes are released from MSC, and MSC-exosomes poorly accumulate in target tissue after systemic administration. In this study, iron oxide nanoparticles (IONP) were introduced to MSC and the exosome-mimetic nanovesicles were isolated. Treatment of IONP contribute to enhanced expression of therapeutic growth factors in MSC, which are attributed to IONP that are slowly ionized to iron ions. Isolated nanovesicles incorporate not only IONP which act as magnet-navigating tool, but also large amount of therapeutic growth factors. In this thesis, in vivo systemic delivery of IONP-harboring nanovesicles and their therapeutic effects in central nervous system lesions or in injured myocardium are presented. |
