| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Synthesis and characterization of biodegradable 70/30 poly(L-lactide-co-glycolide) Copolymer |
| 초록 |
In this study, random copolymerization of 70wt% of L-lactide and 30wt% of glycolide was conducted in bulk using Sn(Oct)2 as a catalyst over a wide range of temperature (from 180℃ to 200℃) and monomer to Sn(Oct)2 molar ratio(from 50ppm to 150ppm). We also used three different chain stopping agents to control molecular weight-Lauryl alcohol, Diethylene glycol (DEG), and Glycolic acid. The results were evaluated with regard to comonomer composition and conversion by means of 1H-NMR, and thermal properties with DSC. Molecular weights were determined by means of viscometry of polymer solution in chloroform and gel-permeation chromatography. Copolymers of L-lactide and glycolide were hydorolysed at 37℃ for periods up to 60 days. The surface morphology of samples was also examined with scanning electron microscope. |
| 저자 |
김현균, 윤혜성, 김선우, 여규동
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| 소속 |
삼양사 의약 (연) |
| 키워드 |
PLGA copolymer; Hydrolytic degradation
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| E-Mail |
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